Überblick / Overview

Mucosal Flora

Functional biostructure of colonic microbiota


Diagnose and monitoring of active Crohn's disease and ulcerative colitis       Kurzfassung in Deutsch


Intestinal Publicationen

Swidsinski A.

Dickdarm-Mikrobiom und S. boulardii.

Medical Tribune Austria 2018 Nr.51-52 (4) 19. Dezember 2018


Swidsinski A, Dörffel Y, Loening-Baucke V, Gille C, Göktas Ö, Reißhauer A, Neuhaus J, Weylandt KH, Guschin A, Bock M.

Reduced Mass and Diversity of the Colonic Microbiome in Patients with Multiple Sclerosis and Their Improvement with Ketogenic Diet.

Front Microbiol. 2017 Jun 28;8:1141. doi: 10.3389/fmicb.2017.01141. eCollection 2017. PMID: 28702003


Swidsinski A, Dörffel Y, Loening-Baucke V, Gille C, Reißhauer A, Göktas O, Krüger M, Neuhaus J, Schrödl W.

Impact of humic acids on the colonic microbiome in healthy volunteers.

World J Gastroenterol. 2017 Feb 7;23(5):885-890. doi: 10.3748/wjg.v23.i5.885. PMID: 28223733


Swidsinski A, Loening-Baucke V, Schulz S, Manowsky J, Verstraelen H, Swidsinski S.

Functional anatomy of the colonic bioreactor: Impact of antibiotics and Saccharomyces boulardii on bacterial composition in human fecal cylinders. Syst Appl Microbiol. 2016 Feb;39(1):67-75. doi: 10.1016/j.syapm.2015.11.002. Epub 2015 Dec 14. PMID:26723852


Margret I Moré, Alexander Swidsinski

Saccharomyces boulardii unterstützt die Regenerierung der intestinalen Mikrobiota bei diarrhoeischen und antibiotischen Dysbiosen.

MMW-Fortschritte der Medizin 2015


Margret I Moré, Alexander Swidsinski

Saccharomyces boulardii CNCM I-745 supports regeneration of the intestinal microbiota after diarrheic dysbiosis – a review.

Clinical and Experimental Gastroenterology 2015 Aug; 8:237-255.


Swidsinski A, Loening-Baucke V, Krüger M, Kirsch S.

Central Nervous System and the Colonic Bioreactor: Analysis of Colonic Microbiota in Patients with Stroke Unravels Unknown

Mechanisms of the Host Defense after Brain Injury.

Intest Res 2012;10(4):332-342


Swidsinski A, Dörffel Y, Loening-Baucke V, Tertychnyy A, Biche-Ool S, Stonogin S, Guo Y, Sun ND.

Mucosal Invasion by Fusobacteria is a Common Feature of Acute Appendicitis in Germany, Russia, and China.

Saudi J Gastroenterol 2012 Jan;18(1):55-8. PubMed PMID: 22249094


Dörffel Y, Swidsinski A, Loening-Baucke V, Wiedenmann B, Marianne Pavel M.

Common Biostructure of the Colonic Microbiota in Neuroendocrine Tumors and Crohn’s Disease and the Effect of Therapy.

Inflamm Bowel Dis. 2011 Nov 23. doi: 10.1002/ibd.21923. [Epub ahead of print] PubMed PMID: 22113988


Swidsinski A, Loening-Baucke V, Kirsch S, Doerffel Y.

[Functional biostructureof colonic microbiota (central fermenting area, germinal stock area and separating

mucus layer) in healthy subjects and patients with diarrhea treated with Saccharomyces boulardii].

Gastroenterol Clin Biol. 2010 Sep;34 Suppl 1:S79-92. French. PubMed PMID: 20889010.


Swidsinski A, Loening-Baucke V, Herber A..

Mucosal flora in Crohn's disease and ulcerative colitis - an overview. J Physiol Pharmacol. 2009 Dec;60 Suppl 6:61-71.PubMed PMID: 20224153.


Swidsinski A, Dörffel Y, Loening-Baucke V, Theissig F, Rückert JC, Ismail M, Rau WA, Gaschler D, Weizenegger M, Kühn S, Schilling J, Dörffel WV.

Acute appendicitis is characterised by local invasion with Fusobacterium nucleatum/necrophorum.

Gut. 2010 May 4. [Epub ahead of print] PubMed PMID: 19926616.


Swidsinski A, Ung V, Sydora BC, Loening-Baucke V, Doerffel Y, Verstraelen H, Fedorak RN.

Bacterial overgrowth and inflammation of small intestine after carboxymethylcellulose ingestion in genetically susceptible mice.

Inflamm Bowel Dis. 2009 Mar;15(3):359-64. PubMed PMID: 18844217.


Swidsinski A, Loening-Baucke V, Verstraelen H, Osowska S, Doerffel Y.

Biostructure of fecal microbiota in healthy subjects and patients with chronic idiopathic diarrhea.

Gastroenterology. 2008 Aug;135(2):568-79. Epub 2008 Apr 18. PubMed PMID: 18570896.


Döerffel Y, Pavel M, Loening-Baucke V, Swidsinski A..

Common biostructure of the fecal flora in celiac disease, Crohn's disease, and carcinoid tumors.

Inflamm Bowel Dis. 2008 Nov;14(11):1613-4. PubMed PMID: 18521905.


Loening-Baucke V, Swidsinski A.

Observational study of children with aerophagia. Clin Pediatr (Phila). 2008 Sep;47(7):664-9. Epub 2008 Apr 29. PubMed PMID: 18445758.


Swidsinski A, Loening-Baucke V, Bengmark S, Scholze J, Doerffel Y.

Bacterial  biofilm suppression with antibiotics for ulcerative and indeterminate colitis: consequences of aggressive treatment.

Arch Med Res. 2008 Feb;39(2):198-204. Epub 2007 Oct 31. PubMed PMID: 18164963.


Swidsinski A, Loening-Baucke V, Vaneechoutte M, Doerffel Y.

Active Crohn's disease and ulcerative colitis can be specifically diagnosed and monitored based on the biostructure of the fecal flora.

Inflamm Bowel Dis. 2008 Feb;14(2):147-61. PubMed PMID: 18050295.


Loening-Baucke V, Swidsinski A.

Constipation as cause of acute abdominal pain in children. J Pediatr. 2007 Dec;151(6):666-9. Epub 2007 Jul 30. PubMed PMID: 18035149.


Sandek A, Bauditz J, Swidsinski A, Buhner S, Weber-Eibel J, von Haehling S, Schroedl W, Karhausen T, Doehner W, Rauchhaus M, Poole-Wilson P, Volk HD, Lochs H, Anker SD.

Altered intestinal function in patients with chronic heart failure.

J Am Coll Cardiol. 2007 Oct 16;50(16):1561-9. Epub 2007 Oct 1. PubMed PMID: 17936155.


Eaves-Pyles T, Allen CA, Taormina, Swidsinski A, Tutt CB, Jezek GE, Islas-Islas M, Torres AG.

Escherichia coli isolated from a Crohn's disease patient adheres, invades, and induces inflammatory responses in polarized intestinal epithelial cells. Int J Med Microbiol. 2008 Jul;298(5-6):397-409. Epub 2007 Sep 27. PubMed PMID: 17900983.


Swidsinski A, Sydora BC, Doerffel Y, Loening-Baucke V, Vaneechoutte M, Lupicki M, Scholze J, Lochs H, Dieleman LA.

Viscosity gradient within the mucus layer determines the mucosal barrier function and the spatial organization

of the intestinal microbiota. Inflamm Bowel Dis. 2007 Aug;13(8):963-70. PubMed PMID: 17455202.


Swidsinski A, Loening-Baucke V, Bengmark S, Lochs H, Dörffel Y.

Azathioprine  and mesalazine-induced effects on the mucosal flora in patients with IBD colitis.

Inflamm Bowel Dis. 2007 Jan;13(1):51-6. PubMed PMID: 17206639.


Swidsinski A..

Standards for  bacterial identification by fluorescence In situ hybridization within eukaryotic  tissue using ribosomal rRNA-based

probes. Inflamm Bowel Dis. 2006 Aug;12(8):824-6; author reply 826-7. PubMed PMID: 16917237.


Swidsinski A, Loening-Baucke V, Theissig F, Engelhardt H, Bengmark S, Koch S, Lochs H, Dörffel Y.

Comparative study of the intestinal mucus barrier in normal and inflamed colon.

Gut. 2007 Mar;56(3):343-50. Epub 2006 Aug 14. PubMed PMID: 16908512; PubMed Central PMCID: PMC1856798.


Canny G, Swidsinski A, McCormick BA.

Interactions of intestinal epithelial cells with bacteria and immune cells: methods to characterize microflora and functional

consequences. Methods Mol Biol. 2006;341:17-35. Review. PubMed PMID: 16799186.


Hale LP, Gottfried MR, Swidsinski A.

Piroxicam treatment of IL-10-deficient mice enhances colonic epithelial apoptosis and mucosal exposure to intestinal bacteria.

Inflamm Bowel Dis. 2005 Dec;11(12):1060-9. PubMed PMID: 16306768.


Swidsinski A, Mendling W, Loening-Baucke V, Ladhoff A, Swidsinski S, Hale LP, Lochs H.

Adherent biofilms in bacterial vaginosis. Obstet Gynecol. 2005 Nov;106(5 Pt 1):1013-23. PubMed PMID: 16260520.


Swidsinski A, Weber J, Loening-Baucke V, Hale LP, Lochs H.

Spatial organization and composition of the mucosal flora in patients with inflammatory bowel disease.

J Clin Microbiol. 2005 Jul;43(7):3380-9. PubMed PMID: 16000463; PubMed Central PMCID: PMC1169142.


Swidsinski A, Loening-Baucke V, Lochs H, Hale LP.

Spatial organization of bacterial flora in normal and inflamed intestine: a fluorescence in situ hybridization study in mice.

World J Gastroenterol. 2005 Feb 28;11(8):1131-40. PubMed PMID: 15754393.


Swidsinski A, Schlien P, Pernthaler A, Gottschalk U, Bärlehner E, Decker G, Swidsinski S, Strassburg J, Loening-Baucke V, Hoffmann U, Seehofer D, Hale LP, Lochs H.

Bacterial biofilm within diseased pancreatic and biliary tracts. Gut. 2005 Mar;54(3):388-95. PubMed PMID: 15710988; PubMed Central PMCID: PMC1774423.


Darfeuille-Michaud A, Boudeau J, Bulois P, Neut C, Glasser AL, Barnich N, Bringer MA, Swidsinski A, Beaugerie L, Colombel JF.

High prevalence of adherent-invasive Escherichia coli associated with ileal mucosa in Crohn's disease.

Gastroenterology. 2004 Aug;127(2):412-21. PubMed PMID: 15300573.


Swidsinski A, Ladhoff A, Pernthaler A, Swidsinski S, Loening-Baucke V, Ortner M, Weber J, Hoffmann U, Schreiber S, Dietel M, Lochs H.

Mucosal flora in inflammatory bowel disease. Gastroenterology. 2002 Jan;122(1):44-54. PubMed PMID: 11781279.


Swidsinski A, Lee SP.

The role of bacteria in gallstone pathogenesis. Front Biosci. 2001 Oct 1;6:E93-103. Review. PubMed PMID: 11578976.


Swidsinski A, Khilkin M, Kerjaschki D, Schreiber S, Ortner M, Weber J, Lochs  H.

Association between intraepithelial Escherichia coli and colorectal cancer. Gastroenterology. 1998 Aug;115(2):281-6. PubMed PMID: 9679033.














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